Sterilization with the Hyalo Matrix

 

What if the biopharmaceutical industry could eliminate the need for cold chain logistics saving the industry billions of dollars every year? What if products such as, genetic materials, attenuated viruses, viral vectors, biologics, antibodies, biosimilars, protein subunits, nanosuspensions, small and large molecular actives, combination products, medical devices, etc. could all be stable, stored, and transported at room temperature or at normal refrigeration in hotter climates?

The answer to solve this global problem is Hyalo Technologies’ Sterilization Method and the Hyalo Matrix. Cold chain logistics could be eliminated by improving product stability and allowing for room temperature storage and transport.

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The Hyalo Technologies Sterilization method adds a Matrix to pharmaceutical products and medical devices and sterilizes them at a lower temperature, prevents product denaturation, maintains efficacy, and enhances stability.

This could eradicate the need for cold chain logistics of storage and transportation as the product is now stable at room temperature, which will make global distribution quicker and more efficient.

Also the need for aseptic processing and specialized sterile rooms would be eliminated, allowing for sterilization to occur at the end of the manufacturing process, which will reduce time and cost.

Applicability: genetic materials, attenuated viruses, viral vectors, protein subunits, nanosuspensions, small and large molecular actives, monoclonal antibodies, combination products, medical devices, lyophilized products, biologics, antibodies, and biosimilars.



Sterilization of Microparticles

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Fig 1: Microscopic picture of large particles without matrix after sterilization at 50 °C

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Fig 2: Microscopic picture of large particles without matrix after sterilization at 37 °C

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Fig 3: Microscopic picture of large particles with matrix after sterilization at 50 °C

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Fig 4: Microscopic picture of large particles with matrix after sterilization at 37  ° C